What are Fat Blockers
The chemicals called Fat Blockers act on water-soluble substrates
means intestinal lipases. For this reason intestinal lipases must be able to adsorb to a lipid-water interface.
The activity of lipases is greatly augmented when fat is emulsified or in a micellar form.
There are three important intestinal lipases:
Carboxyl ester lipase
Gastric lipase begins the process of fat digestion by forming fatty acids and
Diglycerides from dietary triglycerides.
These fatty acids in turn help activate pancreatic lipase. The bulk of triglyceride digestion is accomplished by
pancreatic lipase. In the presence of fatty acids, bile salts and Colipase, pancreatic lipase undergoes a dramatic
conformational change to expose the active site and allow it to digest triglycerides.
Colipase serves to anchor pancreatic lipase to substrate and also to stabilize the lid domain.
Colipase is secreted by the pancreas as Procolipase (an inactive Zymogen form) and is activated by
Trypsin which splits off a Pentapeptide from the N-terminus.
Carboxyl ester lipase
Carboxyl ester lipase hydrolyzes vitamin esters and is therefore important in vitamin absorption.
How Fat Blockers work?
Fat Blocker drug content inhibits all three intestinal lipases. It binds
covalently to serine-152 in the active site and effectively prevents access of
lipase to other dietary triglycerides. Passage of Fat Blocker across the
intestinal Epithelium is exceedingly minimal and does not appear to have an
effect on lipases other than those in the intestinal tract.
Since Fat Blockers are considered as powerful weight loss
drugs, they are available only by doctors prescription and are
characterized with many unwanted side effects. Side effects associated with
Fat Blocker intake are mainly due to unabsorbed fat passing through the
digestive tract and prevents absorption of some essential fat-soluble vitamins too - beta
carotene and vitamins A, D, E and K.
To compensate, you have to take a beta-carotene and a multivitamin with vitamins A,
E, D and K once a day, at least 2 hours before or 2 hours after taking Fat
Blocker drug. These side effects are considerably reduced after one year.
There are many supplements on the open market which are known as Fat Blockers.
Each of those supplements have it's benefits and drawbacks.
They are widely utilized in order to block Fat Absorption into your body but according to
the results of our research we have to warn you about their safety and
side effects that the supplementation can cause.
Among Fat Blockers available on the market we will review
Alli ( XENICAL and
ORLISTAT OTC form).
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