Vitamin Bile Salt Study, Proactol Fat Binder Clinical Data
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Complementary Results: Effects Of Patented Fibre Complex Of Opuntia Ficus Indica On
The Binding Of Non-Specific Fat-Soluble Vitamins, Bile Salts And Acids
In addition to the fat absorption properties of patented fibre complex of Opuntia ficus indica, the
effect on the fat-soluble vitamins A and E as well as on bile salts and acid were examined in vitro and
in a clinical pre-study.
Vitamins A and E:
The fat binding product patented fibre complex of Opuntia ficus indica was added to a mixture of
sunflower oil containing approximately the recommended daily nutritional amount of vitamins A and E.
The test was performed under conditions (aqueous phase, temperature, pH) comparable with those of
the digestive tract. Patented fibre complex of Opuntia ficus indica interacts with the fat content and
decreases the quantity of fat remaining in the medium. By analysing the vitamins in each remaining
fatty phase the capacity of patented fibre complex of Opuntia ficus indica to bind specifically to fatsoluble
vitamins can be evaluated. The results of the in vitro tests show that patented fibre complex of
Opuntia ficus indica does not bind to fat-soluble vitamins A and E in a specific manner. This is
supported by a clinical pre-study. In conclusion, the product does not pose a risk to vitamin levels.
Bile salts and acids:
The effect of fibre, compared to fat, is its ability to initially interact and, if required, bind to bile
salts. Bile salts are necessary to emulsify the nutritional fat so that it can be transformed into fatty
acids by the pancreatic lipase. Bile salts have also an accelerating effect on the transit time. Bile
acids, cholic acid and its derivatives are derived from cholesterol. In the bile, they are combined with
taurine or glycine to increase their hydrophile and emulsifying capacity. Colon bacteria separate the
cholic acid and its combined amino acid, It is through this process that bile acids come to be found in
the stool. The majority of bile salts are reabsorbed at the end of the small intestines and returned to
the liver by blood circulation before they are re-excreted. The pool of bile salts is small (2 to 4 g) but
the entheropatic cycle allows for a flow of 12 to 40 g/24 hours in the intestines.
The concentration of the bile acids is measured on freeze-drying stool samples. The results show that
patented fibre complex from Opuntia ficus indica collects some of the bile acids and makes them
unavailable for digestion of lipids by pancreatic lipase.
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