Tenuate

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Tenuate is a dietary supplement that aims to help with weight loss. Unlike many diet products currently gracing the market, Tenuate requires a doctor’s prescription. This product helps with fat reduction by suppressing the user’s hunger. However, a proper diet and regular exercise are encouraged with Tenuate supplements.

Generic name: Diethylpropion hydrochloride,
Brand name: Tenuate

What is Tenuate?

Tenuate is a sympathomimetic amine, which is similar to an amphetamine. It is also known as an “anorectic” or an “anorexigenic” drug. Tenuate stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite.

Tenuate is used as a short-term supplement to diet and exercise in the treatment of obesity.

Tenuate is available for oral administration in immediate-release tablets containing 25 mg diethylpropion hydrochloride and in controlled-release tablets containing 75 mg diethylpropion hydrochloride.

TENUATE® — (diethylpropion hydrochloride USP) Immediate-Release 25 mg Tablets
TENUATE DOSPAN® — (diethylpropion hydrochloride USP) Controlled-Release 75 mg Tablets

In TENUATE DOSPAN tablets, diethylpropion hydrochloride is dispersed in a hydrophilic matrix. On exposure to water, the diethylpropion hydrochloride is released at a relatively uniform rate as a result of the slow hydration of the matrix. The result is the controlled release of the anorectic agent.

The inactive ingredients in each immediate-release tablet are corn starch, lactose, magnesium stearate, pregelatinized corn starch, talc, and tartaric acid.
The inactive ingredients in each controlled-release tablet are carbomer 934P, mannitol, povidone, tartaric acid, and zinc stearate.

Why is Tenuate prescribed?

Tenuate is an appetite suppressant prescribed for short-term use (a few weeks) as part of an overall diet plan for weight reduction. It is available in two forms: immediate-release tablets (Tenuate) and controlled-release tablets (Tenuate Dospan).
NOTE: Tenuate should be used with a behavior modification program.

What is the most important information I should know about Tenuate?

Tenuate is effective only for short-term treatment and it will lose its effectiveness within a few weeks. When this begins to happen, you should discontinue the medicine rather than increase the dosage.

Tenuate (diethylpropion hydrochloride) immediate-release dosage: One immediate-release 25 mg tablet three times daily, one hour before meals, and in midevening if desired to overcome night hunger.

Tenuate DOSPAN (diethylpropion hydrochloride) controlled-release: One controlled-release 75 mg tablet daily, swallowed whole, in midmorning.

Before taking Tenuate

Use caution when driving, operating machinery, or performing other hazardous activities. Tenuate may cause dizziness, blurred vision, or restlessness, and it may hide the symptoms of extreme tiredness. If you experience these effects, avoid hazardous activities.

Tenuate is habit forming. You can become physically and psychologically dependent on this medication, and withdrawal effects may occur if you stop taking it suddenly after several weeks of continuous use. Talk to your doctor about stopping this medication gradually.

Do not crush, chew, or open any “once-daily” Tenuate tablets or capsules. Swallow them whole.

You cannot take Tenuate if you:

• have heart disease or high blood pressure;
• have arteriosclerosis (hardening of the arteries);
• have glaucoma;
• have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days; or
• have a history of drug or alcohol abuse.

Before taking this medication, tell your doctor if you have:

• problems with your thyroid,
• an anxiety disorder,
• epilepsy or another seizure disorder, or
• diabetes.

You may not be able to take Tenuate, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Tenuate is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take Tenuate without first talking to your doctor if you are pregnant.

Tenuate passes into breast milk and may affect a nursing baby. Do not take Tenuate without first talking to your doctor if you are breastfeeding a baby.

What are the Side Effects of Tenuate

Cardiovascular: Precordial pain, arrhythmia (including ventricular), ECG changes, tachycardia, the elevation of blood pressure, palpitation, and rare reports of pulmonary hypertension. Valvular heart disease associated with the use of some anorectic agents such as fenfluramine and dexfenfluramine, both independently and especially when used in combination, has been reported. Valvulopathy has been very rarely reported with TENUATE or TENUATE DOSPAN monotherapy, but the causal relationship remains uncertain.

Central Nervous System: In a few epileptics an increase in convulsive episodes has been reported; rarely psychotic episodes at recommended doses; dyskinesia, blurred vision, overstimulation, nervousness, restlessness, dizziness, jitteriness, insomnia, anxiety, euphoria, depression, dysphoria, tremor, mydriasis, drowsiness, malaise, headache, and cerebrovascular accident

Gastrointestinal: Vomiting, diarrhea, abdominal discomfort, dryness of the mouth, unpleasant taste, nausea, constipation, and other gastrointestinal disturbances

Allergic: Urticaria, rash, ecchymosis, erythema

Endocrine: Impotence, changes in libido, gynecomastia, menstrual upset

Hematopoietic System: Bone marrow depression, agranulocytosis, leukopenia

Miscellaneous: A variety of miscellaneous adverse reactions has been reported by physicians.

These include complaints such as dysuria, dyspnea, hair loss, muscle pain, increased sweating, and polyuria.

How should you take Tenuate

Take Tenuate exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Tenuate may be habit-forming and can be addicting. If you are taking Tenuate Dospan (the controlled-release formulation), do not crush or chew the tablets. Swallow the medication whole.

• Take each dose with a full glass of water.
• Take Tenuate on an empty stomach 1 hour before meals. An evening dose may be taken to overcome nighttime hunger.
• Tenuate is usually taken three times a day (regular-release formula).

Follow your doctor’s instructions. The sustained-release formulation is usually taken once a day in the mid-morning.

IMPORTANT: Do not crush, chew or open any “once-daily” (long-acting or sustained-release) diethylpropion tablets or capsules. Swallow them whole.

Never take more of this medication than is prescribed for you. Too much Tenuate could be very dangerous to your health.

What happens if you overdose?

Seek emergency medical attention. Symptoms of a Tenuate overdose include restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures.

What should you avoid while taking Tenuate?

Use caution when driving, operating machinery, or performing other hazardous activities. Tenuate may cause dizziness, blurred vision, or restlessness, and it may hide the symptoms of extreme tiredness. If you experience these effects, avoid hazardous activities.

What are the possible side effects of Tenuate?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue using Tenuate. If you experience any of the following serious side effects, stop taking Tenuate and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
an irregular heartbeat or very high blood pressure (severe headache, blurred vision); or hallucinations, abnormal behavior, or confusion.
Other, less serious side effects may be more likely to occur. Continue to take Tenuate and talk to your doctor if you experience:

• restlessness or tremors,
• nervousness or anxiety,
• headache or dizziness,
• insomnia,
• dry mouth or an unpleasant taste in your mouth,
• diarrhea or constipation, or
• impotence or changes in your sex drive.

Tenuate is habit forming. You can become physically and psychologically dependent on this medication, and withdrawal effects may occur if you stop taking it suddenly after several weeks of continuous use. Talk to your doctor about stopping this medication gradually.

However, this isn’t a complete list of side effects and others may occur.

Why should Tenuate not be prescribed?

If you are sensitive to or have ever had an allergic reaction to Tenuate or other appetite suppressants, you should not take Tenuate.

IMPORTANT: Make sure your doctor is aware of any drug reactions you have experienced.

Do not take Tenuate if you have severe hardening of the arteries, an overactive thyroid, glaucoma, or severe high blood pressure, or if you are agitated, have a history of drug abuse, or are taking an MAO inhibitor (antidepressant drug such as Nardil) or have taken one within the last 14 days.

Drugs affect Tenuate

You cannot take Tenuate if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days.

Changes in insulin and other diabetes drug therapies may be necessary during treatment with Tenuate.

Tenuate may reduce the effects of guanethidine (Iselin). This could lead to an increase in blood pressure. Tell your doctor if you are taking guanethidine.

Before taking this medication, tell your doctor if you are taking a tricyclic antidepressant such as amitriptyline (Elavil), amoxapine (Asendin), doxepin (Sinequan), nortriptyline (Pamelor), imipramine (Tofranil), clomipramine (Anafranil), protriptyline (Vivactil), or desipramine (Norpramin). These drugs may decrease the effects of Tenuate.

Drugs other than those listed here may also interact with Tenuate. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Special warnings about Tenuate

Tenuate or Tenuate Dospan may impair your ability to engage in potentially hazardous activities. Therefore, make sure you know how you react to Tenuate before you drive, operate dangerous machinery, or do anything else that requires alertness or concentration.

If you have heart disease or high blood pressure, use caution when taking Tenuate.

This drug may increase convulsions in some epileptics. Your doctor should monitor you carefully if you have epilepsy.

Psychological dependence has occurred while taking Tenuate. Talk with your doctor if you find you are relying on Tenuate to maintain a state of well-being.

The abrupt withdrawal of Tenuate following prolonged use at high doses may result in extreme fatigue, mental depression, and sleep disturbances.

Tenuate or Tenuate Dospan may interact with alcohol unfavorably. Do not drink alcohol while taking Tenuate.

The effects of Tenuate or Tenuate Dospan during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. This drug appears in breast milk. If Tenuate is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.

Do we recommend Tenuate?

In the vast market of diet pills and weight loss products, Tenuate appears to come with a few more restrictions and warnings than most.

On the bright side, this is a diet product that’s been examined by the FDA.

However, Tenuate is a potent pharmaceutical that requires a doctor’s prescription and may result in increased blood pressure, dizziness, depression, restlessness, dry mouth, upset stomach, anxiety and/or vomiting.

In the end, you may want to examine the diet market more closely before selecting a weight loss product like Tenuate, and it’s certainly prudent to consult a physician beforehand.

Under no circumstances should you buy any pharmaceuticals online without a prescription.

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